Genetic and Epigenetic Regulation of Gene Expression

Welcome to the Shen laboratory at the University of California, San Francisco! We are part of the Institute for Human Genetics, and the Department of Neurology.

We study the fundamental mechanisms of transcriptional control.  By investigating how genetic and epigenetic variations contribute to cis-regulatory elements function, we will develop a detailed understanding how cis-regulatory elements contribute to cell fate determination and health. These studies will lead to a better comprehension of development, and will facilitate the improvement and advancement of preventive methods, diagnoses, and treatments for diseases.